J. Clin. Exp. Med. Res., 2017;5(1):713–719

Журнал клінічних та експериментальних медичних досліджень / 2017;5(1):713–719

COMPLEX ASSESSMENT OF PARAMETER CHANGES OF HOMEOSTASIS IN RATS WITH EXPERIMENTAL GASTRITES
КОМПЛЕКСНА ОЦІНКА ЗМІНИ ПАРАМЕТРІВ ГОМЕОС-ТАЗУ ЩУРІВ ПРИ ЕКСПЕРИМЕНТАЛЬНОМУ ГАСТРИТІ

S.Gushcha, B.Nasibullin, E.Bakholdina, A.Oleshko, N.Kalinichenko
Б.А.Насібуллін, С.Г.Гуща, О.І.Бахолдіна, О.Я.Олешко, М.В.Калініченко

Chronic gastritis is an important medical and social problem. Appli-cation of modern diagnostic techniques and drugs are not always effec-tive, so the search for new methods of treatment, their comprehensive study is relevant. Dealing with these issues requires the making of exper-imental models that accelerate the solution of the problem. Objective: To make a model of chronic gastritis, adequate to its pathogenesis and to study the system changes in organism of rats. Experimental chronic gas-tritis (CG) in white rats caused by the introduction into the stomach of the solution of potassium permanganate (potassium permanganate choice due to its fibrosing effect on the blood vessels of gastric wall). The de-velopment of CG accompanied by activation of lipid peroxidation (ele-vated levels of malondialdehyde), inhibition of the activity of the antiox-idant system (catalase activity decreased) and increased content sero-mucoid (inflammation activation). Established imbalance protein-synthesizing function of the organism, the activity of the immune sys-tem; ion regulating kidney function. This confirms that the gastritis is the system pathological process. The received data clarify the understanding of the pathogenesis of this disease and create an experimental basis, which allow expanding the development of diagnosis and treatment of this pathology.