Assessment of the influence of natrium chloride water on the course of toxic liver damage in the experiment

Gushcha S.G., Kucherenko M.P., Nasibullin B.A., Strus O.E., Volyanska V.S., Novikova A.I., Kovalchuk L.I., Romanenko I.Y., Romanenko I.V. Assessment of the influence of natrium chloride water on the course of toxic liver damage in the experiment. PharmacologyOnLine, 2021, 3: 698-706. Available at: https://pharmacologyonline.silae.it/files/archives/2021/vol3/PhOL_2021_3_A077_Gushcha.pdf

The paper presents data on the evaluation of the effectiveness of the use of natural chloride natrium mineralized water (MW) on the condition of the body of rats with alcohol intoxication (AI). Alcoholization lasted 30 days. From 15 to 30 days, the animals received MW. The use of MW in rats on the background of the development of AI had a positive effect on the state of metabolism: the processes of reamination, protein metabolism, energy-dependent transmembrane transport were restored, there was a decrease in the manifestations of hypoxic nature; the activity of endogenous detoxification processes increased and the state in the system of lipid peroxidation and antioxidant protection was restored. Microscopically, the liver parenchyma has improved (lipid and hyaline inclusions disappear, blood circulation increases, dystrophy is reduced ). The obtained data show that the use of sodium chloride MW has a protective effect on the structural and functional state and metabolic parameters of the rats liver.

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