Comprehensive toxic-biological assessment of coniferous extract

Gushcha S., Nasibillin B., Strus О., Bakholdina E., Muratov V., Nikolenko S., Аrabadji M., Plakida A. Comprehensive toxic-biological assessment of coniferous extract. PharmacologyOnLine, 2021, 3: 1442–1453. Available at: https://pharmacologyonline.silae.it/files/archives/2021/vol3/PhOL_2021_3_A157_Gushcha.pdf

The presented work is devoted to a comprehensive assessment of the biological effect of the coniferous extract in dilutions with a concentration of 0.5 g/l and 1.0 g/l on the body of healthy white rats. The features of the physicochemical composition of the coniferous extract and the presence of a bactericidal effect concerning samples of the test culture of Escherichia coli (strain O55K59) were determined. When conducting studies on animals, the toxic impact of coniferous extract in both dilutions was not established. The work results demonstrated structural and functional changes in the internal organs of rats, changes in metabolic parameters, and the state of peripheral blood. Conclusion – both samples have biological activity, the degree of which depends on the concentration of the coniferous extract. Coniferous extract with a concentration of 0.5 g/l has a more gentle effect on the organism of the tested animals.

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