Еffect of exogenous introduction of blood growth factors to enhance the healing processes of slowly healing burn injuries

Kucherenko M. P., Strus O. E., Nasibullin B. A., Gushcha S. G., Kovalchuk L. I., Glushchenko V. Y., Bahrii L. A., Bobro E. V. Еffect of exogenous introduction of blood growth factors to enhance the healing processes of slowly healing burn injuries. PharmacologyOnLine. 2021, 2: 84–88. Available at: https://pharmacologyonline.silae.it/files/archives/2021/vol2/PhOL_2021_2_A011_Kucherenko.pdf

In an experiment on the 40 male white Wistar rats, the authors evaluated the possibility of the influence of the exogenous introduction of blood growth factors on the rate of healing of slowly healing burn injuries. The exogenous supply of blood growth factors to the healing zone was carried out by double administration of platelet-rich plasma. 

The research results showed that the additional supply of blood growth factors to the wound area does not affect the intensity of the inflammatory process in it. But, at the same time, the number of fibrous fibers and fibroblasts in the wound increases, the structure of the vessels is restored, the number of neutrophils decreases; the intensity of reparative processes increases significantly. Such changes in the intensity of reparative processes provide a decrease of the wound area, an improvement of its appearance, and less involvement of the surrounding tissues.

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