Long-term studies of the chemical composition and biological activity of silt-sulfide peloids of the Kuyalnitsky estuary
Gushcha S. G., Nasibullin B. A., Koeva K. А., Аrabadji М. V. Badiuk N. S., Kysylevska A. Yu. Long-term studies of the chemical composition and biological activity of silt-sulfide peloids of the Kuyalnitsky estuary. PharmacologyOnLine. 2021, 2: 753-760. Available at: https://pharmacologyonline.silae.it/files/archives/2021/vol2/PhOL_2021_2_A085_Gushcha.pdf
Due to anthropogenic impact and climate change, the Kuyalnitsky estuary (Odessa region, Ukraine) has undergone specific changes, which affected the physicochemical composition of the silt-sulfide peloids of the Kuyalnik resort (southern part of the Kuyalnitsky estuary). As a result of these changes, there were corresponding changes in their biological activity. To study the dynamics of these changes, experimental studies of the effect of peloid applications on the structural and functional state of the kidneys of white mice were carried out for the period from 2008 to 2020. If in 2008, the response from the functional state of the kidneys of contact rats was characterized as typical for the effect of moderately mineralized silt-sulfide peloids – a decrease in the volume of daily diuresis due to an increase in tubular reabsorption and an increase in the excretion of potassium and sodium ions against the background of a decrease in the excretion of chlorine ions, then already in 2016, the nature of the response from the outside changed somewhat but remained similar in direction and strength. In 2018, the nature of the response changed dramatically, which manifested itself in a significant increase in the volume of daily urine output only due to a considerable acceleration of GFR, which was accompanied by a significant increase in the excretion of creatinine, urea, sodium and chlorine ions. In 2020, the functional state of the kidneys was characterized by even more powerful negative changes, accompanied by acidification of urine, a significant increase in urea excretion against the background, of a substantial increase in the content of urea and creatinine in the blood. During the same period of research, with a microscopic study of the kidneys, signs of structural changes in the region of the renal glomeruli were first established. The data obtained indicate that the biological activity of peloids has undergone specific negative changes, which should be taken into account when carrying out balneological procedures.