English
Українська
Research of the effectiveness of the influence of mineral silicon-sodium chloride water on the course of the pathology of the gastrointestal tract in the experiment
Nasibullin B. A., Gushcha S. G., Dragomiretska N. V., Strus О. Е., Izha A. N., Badiuk N. S., Volyanska V. S. Research of the effectiveness of the influence of mineral silicon-sodium chloride water on the course of the pathology of the gastrointestal tract in the experiment. PharmacologyOnLine. 2021, 2: 768–775. Available at: https://pharmacologyonline.silae.it/files/archives/2021/vol2/PhOL_2021_2_A087_Nasibullin.pdf
In an experiment in white rats with a reproduced gastritis model, the effectiveness of the use of natural silicon salt sodium mineral water was investigated. Morphological studies at the end of the experiment macroscopically determined that the gastric mucosa is pink-brownish in color, the folds are visually somewhat coarse but of the usual height. Microscopically, the disappearance of manifestations of inflammation in the wall of the stomach was established. In the epithelial cells of the glands of the gastric mucosa, the activation of redox enzymes was established. The activity of redox enzymes (succinate dehydrogenase and lactate dehydrogenase) in the tissues of the stomach increases. The use of MW against the background of the reproduction of the gastritis model has a positive effect on the parameters of the peripheral blood and the immune system: a significant decrease in the percentage of neutrophils, restoration of the number of leukocytes and the hemoglobin content was established; restoration of the percentage of total T-lymphocytes, the range of circulating immune complexes and a significant decrease in the scope of antibodies to stomach tissue. The data obtained showed the feasibility of using silicon salt sodium mineral water in rats with experimental gastritis.
