The involvement of brain specific proteins in the pathogenesis of the consequences of closed pulmonary cranial injury
Gozhenko A. I., Korshnyak V. A., Nasibullin B. A., Savytskyi I. V., Gushcha S. G., Badiuk N. S. The involvement of brain specific proteins in the pathogenesis of the consequences of closed pulmonary cranial injury. PharmacologyOnLine, 2021, 1: 6-11. Available at:
The authors carried out a complex experimental and clinical study using 30 white Wistar rats of autobred breeding, body weight 180–200 g and data obtained in the study of 28 patients with MILD TBI at the age of 25–43 years and MILD TBI 2-5 years old. the aim of the work was to assess the relationship between structural changes in brain matter, clinical manifestations and the content of some regulatory molecules in MILD TBI. Studies have revealed similar changes in cognitive functions and indicators of autonomic status in experimental animals and patients with MILD TBI. At the same time, structural changes in the cortex, thalamic and hypothalamic regions occurred in the brain of the experimental animals, similar to the descriptions found in individuals with TBI.
The examined patients showed changes in the content of regulatory molecules (brain-specific proteins, BDNF, melatonin).
The authors believe that damage to neurons and neuronal populations in TBI leads to dysregulation of the functional systems of the brain, including humoral mechanisms, which determines the formation of clinical manifestations. At the same time, the disorder of humoral regulatory mechanisms through which the functions of controlling the vital activity of the cellular elements of the brain are realized complicates the restoration of functional systems, which contributes to the chronicity of the clinical manifestations of MILD TBI.
All human studies were conducted in compliance with the rules of the Helsinki Declaration of the World Medical Association “Ethical principles of medical research with human participation as an object of study”. Informed consent was obtained from all participants.